Rubral tremor associated with cavernous angioma of the midbrain

1999 ◽  
Vol 14 (1) ◽  
pp. 191-193 ◽  
Author(s):  
G. K. K. Leung ◽  
Y. W. Fan ◽  
S. L. Ho
The Lancet ◽  
1933 ◽  
Vol 222 (5731) ◽  
pp. 13-15 ◽  
Author(s):  
RalphA. Broderick
Keyword(s):  

Neurosurgery ◽  
1991 ◽  
pp. 924 ◽  
Author(s):  
L Mastronardi ◽  
L Ferrante ◽  
M Scarpinati ◽  
F M Gagliardi ◽  
P Celli ◽  
...  

2002 ◽  
Vol 249 (10) ◽  
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Paolo Cerrato ◽  
Mauro Bergui ◽  
Daniele Imperiale ◽  
Chiara Baima ◽  
Maria Grasso ◽  
...  

1993 ◽  
Vol 241 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Luigi Mossuto-Agatiello ◽  
Giovanni Puccetti ◽  
Anna Elisa Castellano

2009 ◽  
Vol 49 (10) ◽  
pp. 474-477 ◽  
Author(s):  
Kosei IJIRI ◽  
Kazutoshi HIDA ◽  
Shunsuke YANO ◽  
Yoshinobu IWASAKI

Author(s):  
Diogo Goulart Corrêa ◽  
Luis Alcides Quevedo Cañete ◽  
Luiz Celso Hygino da Cruz

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Je Yeong Sone ◽  
Nicholas Hobson ◽  
Sharbel Romanos ◽  
Abhinav Srinath ◽  
Abdallah Shkoukani ◽  
...  

Introduction: Diagnosis of cavernous angioma with symptomatic hemorrhage (CASH) requires MRI evidence of lesional bleeding associated directly with attributable symptoms. However, hemorrhagic signs of CASH may become clinically silent on conventional MRI after 3 months. As CASH is likely to rebleed for several years, accurate diagnosis of CASH that bled more than 3 months prior is needed. Hypothesis: Perfusion and permeability derivations of dynamic contrast-enhanced quantitative perfusion (DCEQP) MRI can diagnose CASH and predict bleeding/growth in CAs. Methods: CAs of 205 consecutively enrolled patients scanned with DCEQP during clinical visits were classified as CASH that bled 3 - 12 months prior (N = 55) versus non-CASH (N = 658) or CA with (N = 23) versus without (N = 721) bleeding/growth within a year after MRI. Demographics and 13 perfusion and 13 permeability derivations of DCEQP were assessed via machine learning and univariate analyses. Logistic regression models ln ( P / 1 - P ) = Σ (β i x i ) + β 0 were selected as the best diagnostic and prognostic biomarkers by minimizing the Bayesian information criterion (BIC). Results: The best diagnostic biomarker of CASH that bled 3 - 12 months prior (BIC = 321.6, Figure A) showed 80% sensitivity and 82% specificity. Permeability derivations did not add diagnostic efficacy when combined with perfusion. The best prognostic biomarker of bleeding/growth (BIC = 201.5, Figure B) showed 77% sensitivity and 72% specificity. Conclusion: Perfusion imaging may diagnose CASH even after hemorrhagic signs disappear on conventional MRI. A combination of permeability and perfusion derivations may help predict bleeding/growth in CAs.


BMJ Open ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. e025533 ◽  
Author(s):  
San San Xu ◽  
Paschal K Alexander ◽  
Yenni Lie ◽  
Vincent Dore ◽  
Svetlana Bozinovski ◽  
...  

ObjectivesTo further validate the diagnostic utility of 18F-AV-133 vesicular monoamine transporter type 2 (VMAT2) positron emission tomography (PET) in patients with clinically uncertain parkinsonian syndromes (CUPS) by comparison to clinical diagnosis at 3 years follow-up.Design, setting and participantsIn a previous study, we reported that 18F-AV-133 PET in community patients with CUPS changed diagnosis and management and increased diagnostic confidence. The current diagnosis of this cohort was obtained from the patient and treating specialist and compared with the diagnosis suggested 3 years earlier by the 18F-AV-133 PET. A second 18F-AV-133 PET was available in those with a discordant or inconclusive final diagnosis.Study outcome measuresThe primary end point was the proportion of patients who had a follow-up clinical diagnosis, which was concordant with their initial 18F-AV-133 PET scan. Secondary end points were the proportion of patients who had the same diagnosis at follow-up as that reached after the initial scan and the stability of diagnostic changes made after the first scan.Results81 of the 85 patients previously recruited to the CUPS study had follow-up of which 79 had a clinical diagnosis and 2 remained CUPS. The diagnosis was in agreement with the initial 18F-AV-133 PET scan result in 74 cases. Five patients had a discordant diagnosis; one patient with rubral tremor had a severely abnormal scan that had worsened when rescanned; four cases with normal initial and repeat scans had a clinical diagnosis of Parkinson’s disease. Two patients with suspected genetic disorders remained classified as CUPS and both had normal scans. In the 24 CUPS cohort patients where 18F-AV-133 PET initially changed diagnosis, this change was supported by follow-up diagnosis in all but the one rubral tremor case.Conclusion18F-AV-133 PET is a useful tool in improving diagnostic accuracy in CUPS providing results and diagnostic changes that remain robust after 3 years follow-up.


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